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Background  Genetic variants of the  FTO  gene rs9939609 A/T and the  MC4R  gene rs17782313 C/T have been associated with obesity. Individuals with mutations in  MC4R  gene have lower blood pressure (BP), independently of obesity. This study aimed to investigate the association of  FTO  rs9939609 and  MC4R  rs17782313 with anthropometric indexes, BP, and type 2 diabetes mellitus among hypertensive patients.    Methods  We genotyped 217 individuals (86 men and 131 women) with hypertension (systolic or diastolic BP ≥ 140/90 mmHg or using antihypertensive drugs). Diabetes mellitus was diagnosed according to the American Diabetes Association criteria. Waist and neck circumferences (cm), Body Adiposity Index (BAI,%), Lipid Accumulation Product Index (LAP, cm.mmol.l) and body mass index (BMI, kg/m 2 ) were analyzed using analysis of covariance or modified Poisson’s regression.    Results  Rare allele frequencies were 0.40 for A for  FTO  rs9939609 and 0.18 for C for  MC4R  rs17782313. A positive association of  FTO  rs9939609 and  MC4R  rs17782313 with BMI was observed in the overall sample. Among men and women, neck circumference was associated with the  FTO  genotype and, for women,  MC4R  genotype. In contrast, in men we found a negative association of  MC4R  rs17782313 with diastolic BP (TT 90.1 ±12.2, TC/CC 83.2 ±12.1; P = 0.03) and borderline association for systolic BP after controlling for age and BMI.    Conclusions  Common genetic variants of  FTO  rs9939609 have positive associations with BMI and neck circumference and  MC4R  rs17782313 in women, but a negative association with diastolic and mean blood pressure in men with hypertension.

Effects of FTO RS9939906 and MC4R RS17782313 on obesity, type 2 diabetes mellitus and blood pressure in patients with hypertension