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Background Previous studies reported substantial contributions of neurofibrillary tangles, amyloid deposits, and neuronal loss to the development of dementia. However, the prediction of cognitive status based on non-stereologic quantification of these parameters has led to conflicting results. Such studies have measured densities, rather than absolute numbers, and most do not take into account the potential interaction between the above pathological hallmarks in a global multivariate analysis.

Tangles and neuron numbers but not amyloid load predict cognitive status in Alzheimer's disease