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Background The diagnosis of Parkinson Disease (PD) has been based on clinical criteria when approximately 70–80% of the nigrostriatal neurons of the substantia nigra (SN) are degenerated. Early diagnosis can be essential for an effective treatment. Latest developments, like PET with 18F-LDOPA or SPECT with (123) I, try to identify PD in an earlier state by measure the degeneration of dopamine nerve cells. Pupillometry, detects pupil reaction to light which is subserved by subcortical projections, can be combined with this techniques to provide useful data for diagnosis and progression of PD.

Pupillometry in Parkinson disease, correlation with Dat Scan findings