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Background Several lines of evidence suggest that suicidal behavior has a genetic component. Low serotoinergic activite is associated with suicidal behavior. Alterations in binding kinetics of 2A (HTR2A) and 1B (HTR1B) serotonin receptors are reported postmortem in the brain of suicide victims compared with nonsuicides. So, HTR2A and HTR1B genes are the main candidate genes of suicidal behavior. The aim of our investigation is to examine the relationships of attempted suicide with A-1438G polymorphism of HTR2A gene and G-861C polymorphism of HTR1B gene.

The 2A and the 1B serotonin receptor genes as candidate genes of suicidal behavior