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Background   Allamanda cathartica. L.  is a perennial shrub used in traditional medicine for treating malaria and jaundice.  Laurus nobilis .  L.  is a tree and has been used for its astringent, healing and diuretic properties. The objective of this study was to investigate the aqueous extracts of  Allamanda  and  Laurus nobilis  to evaluate their wound healing activity in rats.    Methods  Excision and incision wound models were used to evaluate the wound healing activity of both the extracts on Sprague Dawley rats. In each model, animals were divided into four groups of 10 animals each. In both the model, group 1 served as control and group 2 as reference standard. In an excision wound model, group 3 animals were treated with  Allamanda  (150 mg kg -1  day -1 ) and group 4 animals were treated with  Laurus nobilis  (200 mg kg -1  b.w day -1 ) for 14 days respectively. In the case of incision wound model, group 3 and 4 animals were treated with the extracts of  Allamanda  and  Laurus respectively  for 10 days. The effects of vehicles on the rate of wound healing were assessed by the rate of wound closure, period of epithelialisation, tensile strength, weights of the granulation tissue, hydroxyproline content and histopathology of the granulation tissue.    Results  The aqueous extract of  Allamanda  promoted wound healing activity significantly in both the wound models studied. High rate of wound contraction (P < .001), decrease in the period of epithelialisation (10.2 ± 0.13), high skin breaking strength (440.0 ± 4.53), significant increase in the weight of the granulation tissue (P < .001) and hydroxyproline (P < .001) content were observed in animals treated with the aqueous extract of  Allamanda . Histological studies of the granulation tissue from the  Allamanda  treated group showed the presence of a lesser number of inflammatory cells, and increased collagen formation than the control. In  Laurus nobilis  treated animals, the rate of wound contraction, weight of the granulation tissue and hydroxyproline content were moderately high (P < .05). The histological study of the granulation tissue of the  Laurus nobilis  treated animals showed larger number of inflammatory cells, and lesser collagen when compared with the  Allamanda  treated group of animals. However, it was better than the control group of animals.    Conclusion  The data of this study indicated that the leaf extract of  Allamanda  possesses better wound healing activity than the  Laurus nobilis  and it can be used to treat different types of wounds in human beings too.

Evaluation of wound healing activity of Allamanda cathartica. L. and Laurus nobilis. L. extracts on rats