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Background  Previous data indicate that purified components of ginseng can inhibit HIV reverse transcriptase  in vitro , suggesting that ginseng components in plasma may interfere with HIV-1 RNA detection assays.    Methods  Pre- and post-dose plasma from three volunteers dosed with 3000 mg American ginseng was spiked with HIV and analyzed by the Roche COBAS Ampliprep/Taqman v2.0 HIV-1 RNA assay.    Results  Presence of American ginseng had no significant effect on measured HIV-1 RNA concentration. Variation within pre- and post-dose plasma pair was insignificant and within assay performance limits.    Conclusion  Plasma from subjects dosed with 3000 mg American ginseng does not interfere with the Roche COBAS Ampliprep/Taqman v2.0 HIV-1 RNA assay. This implies that  in vitro  inhibition of HIV reverse transcriptase by American ginseng components is unlikely to be clinically relevant.

American ginseng (Panax quinquefolius) administration does not affect performance of the Roche COBAS Ampliprep/Taqman HIV-1 RNA assay