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Background   Polygonum minus  Huds.is a culinary flavouring that is common in South East Asian cuisine and as a remedy for diverse maladies ranging from indigestion to poor eyesight. The leaves of this herb have been reported to be high in antioxidants. Flavonoids which have been associated with memory, cognition and protection against neurodegeneration were found in  P. minus .    Method  This study examined a  P. minus  aqueous extract (Lineminus ™ ) for its antioxidant activity using the Oxygen Radical Absorbance Capacity (ORAC) assay, the  ex vivo  Cellular Antioxidant Protection of erythrocytes (CAP-e) assays and for potential anticholinesterase activity  in vitro . Cognitive function and learning of Lineminus ™  was evaluated using scopolamine induced cognition deficits in a Barnes maze, rodent model of cognition.    Results  The extract displayed  in vitro  antioxidant activity with a total ORAC value of 16,964 μmole TE/gram. Cellular antioxidant protection from free radical damage using the CAP-e assay, with an IC50 of 0.58 g/L for inhibition of cellular oxidative damage, was observed. The extract inhibited cholinesterase activity with an IC50 of 0.04 mg/ml with a maximum inhibition of 68%. In a rodent model of cognition using scopolamine induced cognition deficits in the Barnes maze, the extract attenuated scopolamine induced disruptions in learning at the higher dose of 100 mg/kg.    Conclusion  These data shows that  P. minus  possesses antioxidant and anticholinesterase activity and demonstrated enhanced cognition  in vivo . The data suggest neuroprotective properties of the extract.

bmc complementary and alternative medicine

In vitro and ex-vivo cellular antioxidant protection and cognitive enhancing effects of an extract of Polygonum minus Huds (Lineminus™) demonstrated in a Barnes Maze animal model for memory and learning