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Background   Morus alba  has long been used in traditional Chinese medicine to treat inflammatory diseases; however, the scientific basis for such usage and the mechanism of action are not well understood. This study investigated the action of  M. alba  on leukocyte migration, one key step in inflammation.    Methods  Gas chromatography-mass spectrometry (GC-MS) and cluster analyses of supercritical CO 2  extracts of three  Morus  species were performed for chemotaxonomy-aided plant authentication. Phytochemistry and CXCR4-mediated chemotaxis assays were used to characterize the chemical and biological properties of  M. alba  and its active compound, oxyresveratrol. fluorescence-activated cell sorting (FACS) and Western blot analyses were conducted to determine the mode of action of oxyresveratrol.    Results  Chemotaxonomy was used to help authenticate  M. alba.  Chemotaxis-based isolation identified oxyresveratrol as an active component in  M. alba . Phytochemical and chemotaxis assays showed that the crude extract, ethyl acetate fraction and oxyresveratrol from  M. alba  suppressed cell migration of Jurkat T cells in response to SDF-1. Mechanistic study indicated that oxyresveratrol diminished CXCR4-mediated T-cell migration via inhibition of the MEK/ERK signaling cascade.    Conclusions  A combination of GC-MS and cluster analysis techniques are applicable for authentication of the  Morus  species. Anti-inflammatory benefits of  M. alba  and its active compound, oxyresveratrol, may involve the inhibition of CXCR-4-mediated chemotaxis and MEK/ERK pathway in T and other immune cells.

Morus alba and active compound oxyresveratrol exert anti-inflammatory activity via inhibition of leukocyte migration involving MEK/ERK signaling