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Background   Buyang Huanwu Decoction  ( BYHWD ), a traditional Chinese medicine formula, has been shown to exert a variety of pharmacological effects including neuroprotective properties. However, the mechanism of neuroprotection is not fully understood. This study was designed to explore the mechanism of  BYHWD  in the treatment of spinal ischemia-reperfusion injury in rats.    Methods  Twenty-eight male Sprague–Dawley rats, weighting 250–280 g, were used, and were randomly divided into four groups with 7 animals in each: sham operation group (Control), spinal ischemia with saline (SI + Saline), spinal ischemia with  BYHWD  (SI +  BYHWD ), and spinal ischemia with roscovitine (SI + R). After 60 minutes of spinal ischemia followed by 72 hours of reperfusion, motor function of hind limbs, spinal ischemic infarction volume, the number of apoptotic cells, and cyclin-dependent kinase 5 (Cdk5) were examined.    Result  Ischemia-reperfusion resulted in injury of the spines, while  BYHWD  significantly improved spinal function. The spinal infarction volume, number of apoptotic cells, and Cdk5 were decreased by administration of  BYHWD . The similar improvements were seen with the pre-treatment of roscovitine.    Conclusions   BYHWD  prevented the ischemia-reperfusion-induced spinal injury in rats. The protective function of  BYHWD  was, in part, linked with inhibition of Cdk5.

bmc complementary medicine and therapies

RETRACTED ARTICLE: Neuroprotective effect of Buyang Huanwu Decoction on spinal ischemia-reperfusion injury in rats is linked with inhibition of cyclin-dependent kinase 5