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Background  Angiogenesis is closely related to the growth, invasion and metastasis of tumors, also considered as the key target of anticancer therapy.  Scutellaria barbata  D. Don ( S. barbata ), a traditional Chinese medicine, is being used to treat various diseases, including cancer. However, the antitumor molecular mechanism of  S. barbata  was still unclear. This study aimed to investigate the inhibitory effects of the total flavones in  S. barbata  (TF-SB) on angiogenesis.    Methods  Human umbilical vein endothelial cells (HUVECs) were treated with various concentrations of TF-SB. Cell viability was examined using the MTT assay. The scratch assay was used to detect the migration of HUVECs after treatment with TF-SB. The ability of HUVECs to form network structures  in vitro  was demonstrated using the tube formation assay. The chick embryo chorioallantoic membrane assay was performed to detect the  in vivo  anti-angiogenic effect. The expression of VEGF was measured by the enzyme-linked immunosorbent.    Results  Results showed that TF-SB inhibited the proliferation and migration of HUVECs in a dose- dependent manner. Simultaneously, TF-SB significantly suppressed HUVEC angiogenesis  in vitro  and  in vivo . Furthermore, VEGF was downregulated in both HUVECs and MHCC97-H cells after TF-SB treatment.    Conclusion  TF-SB could suppress the process of angiogenesis  in vitro  and  in vivo . TF-SB potentially suppresses angiogenesis in HUVECs by regulating VEGF. These findings suggested that TF-SB may serve as a potent anti-angiogenic agent.

Anti-angiogenic effect of the total flavonoids in Scutellaria barbata D. Don