English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background: Elevated LDL cholesterol and impaired fasting glucose are significant risk factors for cardiovascular disease; the most prevalent cause of mortality in the USA. Many dietary approaches have been examined to help combat these medical problems. Each type of diet typically places a particular emphasis on the relative proportions of the three macronutrients; fat, carbohydrate and protein. Methods: We report on a case series of 41 patients who were placed on an 1100 calorie diet reduced in starch and emphasizing lean proteins, mono and polyunsaturated fats and fiber with a unique composition of macronutrients for four months in an effort to improve cholesterol and fasting glucose indices. Results: 28 of the 41 (68%) patients complied with the protocol over a four-month period. In the compliant group, statistically significant reduction (p < 0.05) in the following mean variables were seen; Weight (2.3kg), Total Cholesterol 22% (53 mg/dL), LDL 23% (43mg/dL), HDL (4 mg/dL) ,TAG (21mg/dL) and fasting serum glucose (12mg/dL), after 4 months on the dietary regimen. In the non-compliant/comparison group, statistically significant increase (p < 0.05) in the following variables were seen; Total Cholesterol (24 mg/dL), LDL (14 mg/dL) and TAG (29 mg/dl), at the end of 6 months. Conclusions: This magnitude of reduction in Total and LDL Cholesterol is significantly greater than that seen in the recent large dietary intervention trials and is comparable to that seen in ‘eco-Atkins’ trial, which was far more restrictive in nature and shorter in duration. We hypothesize that given the significant reduction in fasting serum glucose and the pre-clinical data showing insulin increasing activity of the HMG CoA reductase enzyme, the underlying mechanism of action for the significant drop in Total and LDL cholesterol may be a reduced serum insulin levels and HMG-CoA reductase activity.

P02.01. A dietary approach for treating dyslipidemia and hyperglycemia