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Global: Zendy Plus annual

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Methods The experiments were approved by the institution ethics committee under protocol n. 23080.006492/2011-61. Male Swiss mice were randomly divided in the following groups (n=8): naive, control (not treated), Off (LED device turned off), LEDT 1, 3, 5, 7 and 9 (treated with energy densities of 1 through 9 J/cm2). Control, Off and LEDT groups were submitted to a 5mm longitudinal PI (right hindpaw) under anesthesia (1-2% isoflurane). Mechanical hypersensitivity (MH) was assessed as withdrawal frequency percentage to 10 presentations of a 0.4g von Frey filament. Evaluations were conducted before and on day 1 through 5 after PI. LEDT (MOLIMEDpen device; 950 nm wavelength, 80 mW/cm2 irradiance; 1 to 9 J/cm2 energy density) was applied directly to the skin of the incision site.

P01.51. Light-emitting diode therapy reduces mechanical hypersensitivity induced by plantar incision model in mice via opioid mechanism