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mechanical hypersensitivity [all treatment days (p<0.05 p<0.001)] and (2) paw volume [PO day 4, 5 (p <0.001) and 6 (p <0.05)]. One-way ANOVA followed by Newman-Keuls indicated increase in the levels of IL-10 [Sham vs Sham + EC (p<0.01), IR vs IR + EC (p<0.05)] as well as IL-1ra (Sham vs Sham + EC and IR vs IR + EC (p<0.05)]. Conclusion EnergyCare™ presented analgesic and antiedematogenic effects in the mice model of IR of the paw, as well as induced increase of IL-10 and IL-1ra cytokine levels (paw skin and intraplantar muscles).

bmc complementary and alternative medicine

P01.47. Analgesic and antiedematogenic effect of Energycare™ in the mice model of ischemia-reperfusion of the paw: involvement of anti-inflammatory cytokines