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Methods In the two-year POUNDS (Preventing Overweight Using Novel Dietary Strategies) LOST trial, overweight and obese adults were randomly allocated to one of four weight loss diets with targeted percentages of energy derived from fat/protein/carbohydrates (20/15/65%; 20/ 25/55%; 40/15/45%; 40/25/35%, respectively). All participants received tailored diet prescriptions with a 750 kilocalorie deficit from energy expenditure, and an intensive behavioral program accompanied all diet assignments. hsCRP as well as cardiovascular and metabolic factors were measured at baseline, 6, and 24 months among 710 participants.

OA02.01. Effect of macronutrient composition of weight loss diets on reduction of the inflammatory marker hsCRP