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Purpose Previous studies suggest acupuncture analgesic effects involve the release of endogenous opioid peptides. We have previously shown that while both acupuncture and sham reduced clinical pain in fibromyalgia (FM), only acupuncture increased mu-opioid receptor (MOR) baseline receptor availability in vivo (binding potential, BP). Here we investigated whether real and sham acupuncture were associated with differential changes in MOR BP in FM patients that were naive to acupuncture as compared to conditioned patients.

bmc complementary and alternative medicine

OA08.02. Differential acute effects of real and sham acupuncture on mu-opioid receptor availability in treatment naive and conditioned chronic pain patients