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Purpose Health economic studies gain more and more importance in both conventional and complementary medicine. In most cases such studies are conducted as a combination of a RCT and a health economic evaluation (“Piggy-Back-Studies”). Therefore study planning parameters like sample size still are calculated on the basis of the outcome of the clinical parameters. This might lead to situations of underpowering.

OA01.03. Sample size and regions of principally achievable significance in cost effectiveness studies: an example of complementary medicine