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Background  Our previous studies indicated that oxidative stress up-regulated the expression of β-amyloid precursor protein cleavage enzyme-1 (BACE1) in rat retina. Pharmacological reports have shown Timosaponin-BII, a purified extract originating from Chinese medical herb  Rhizoma Anemarrhenae,  is characterized as an antioxidant. Our present study aimed to determine whether Timosaponin-BII affected the expression of BACE1, β-amyloid precursor protein cleavage production of Aβ1-40 and β-C-terminal fragment (β-CTF) in rat retina, which were pre-treated with the oxidizing agent (solution of FeCl 3 ).    Results  Few distinctions of BACE1 distribution were observed among all groups (normal control group, model group, Timosaponin-BII treated and vehicle control groups). Rat retinas in model group and vehicle control group manifested an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF were increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 ( p <0.05) and accumulated less Aβ1-40 or β-CTF ( p <0.05). It also showed significantly decreased level of MDA ( p <0.05) and prolonged partial thromboplastin time ( p <0.05).    Conclusion  Our data suggested that Timosaponin-BII remarkably inhibited the up-regulation of BACE1 and reduced the over-production of β-CTF and Aβ in rat retina, which was induced by FeCl 3 . The mechanism of Timosaponin-BII on BACE1 expression may be related to its antioxidant property.

Timosaponin-BII inhibits the up-regulation of BACE1 induced by Ferric Chloride in rat retina