English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background   Gentiana floribunda  was investigated for the possible hypotensive and vasodilator activities in an attempt to rationalize its traditional use in hypertension.    Methods  The crude extract of  Gentiana floribunda  (Gf.Cr) was studied in anaesthetized rats and isolated thoracic aorta tissues.    Results  Gf.Cr which tested positive for presence of flavonoids, saponins, sterols, tannins and terpenes caused dose-dependent (3.0-100 mg/kg) fall in arterial blood pressure (BP) of rats under anaesthesia. In rat aortic ring preparations denuded of endothelium, Gf.Cr at concentration range of 1.0-10 mg/mL relaxed high K +  (80 mM) and phenylephrine (PE, 1 μM)-induced contractions and shifted Ca ++  dose–response curves to right, similar to that caused by verapamil. It also suppressed PE (1 μM) control peak responses at 0.3-1.0 mg/mL, obtained in Ca ++ -free medium, as exhibited by verapamil. Pre-treatment of tissues with Gf.Cr produced rightward non-parallel shift of PE-curves with decline of maximum contractile response. The vasodilator effect of Gf.Cr was endothelial-independent, as it was not blocked by N ω -nitro-L-arginine methyl ester hydrochloride, atropine and indomethacin in endothelium-intact aortic tissues.    Conclusions  These data indicate that BP-lowering action of  Gentiana floribunda  occurred via Ca ++  antagonism (inhibition of Ca ++  ingress and release from intracellular stores), which provides pharmacological basis to justify its effectiveness in hypertension.

Hypotensive effect of Gentiana floribunda is mediated through Ca++ antagonism pathway