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Background  Cellular damage induced by free-radicals like Reactive Oxygen and Nitrogen Species (ROS and RNS) has been implicated in several disorders and diseases, including ageing. Hence naturally occurring anti-oxidant rich-herbs play a vital role in combating these conditions. The present study was carried out to investigate the  in vitro  free-radical quenching capacity of a known  Ayurvedic  poly-herbal formulation called  Vayasthapana Rasayana.Methods  Methanol extracts of  Vayasthapana Rasayana  formulation (VRF) were studied for  in vitro  total antioxidant activity along with phenolic content and reducing power.  In vitro  assays like DPPH, FRAP, ABTS scavenging to evaluate radical quenching potential were performed.    Results  The formulation has shown 94% at 0.1 mg/ml DPPH free-radical scavenging activity as against 84% at 0.1 mg/ml for standard ascorbic acid (IC 50  value 5.51 μg/ml for VRF and 39 μg/ml for standard). It has a significant higher ferric reducing potential also (OD 0.87 at 700 nm & 0.21 at 0.1 mg/ml for VRF and standard, respectively). The total phenolic content (gallic acid equivalent) of the VRF is 8.3 mg per g of dry mass. Total antioxidant capacity of the formulation, estimated by FRAP was 1150 ± 5 μM Fe(II)/g dry mass. ABTS radical scavenging activity of VRF was 69.55 ± 0.21% at 100 μg/ml concentration with a IC 50  value of 69.87 μg/ml as against 9% and 95% by ascorbic acid and Trolox (at 70.452 μg/ml and 0.250 μg/ml concentrations, respectively).    Conclusion  In Indian traditional  Ayurvedic  system, use of VRF is in regular practice for mainly combating age-related disorders and diseases as many of the components of the  Rasayana  are known for their free-radical scavenging activity. This study has validated the potential use of VRF as an anti-oxidant to fight age-related problems.

Evaluation of free-radical quenching properties of standard Ayurvedic formulation Vayasthapana Rasayana