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Background  Vaginal candidiasis is a frequent and common distressing disease affecting up to 75% of the women of fertile age; most of these women have recurrent episodes. Essential oils from aromatic plants have been shown to have antimicrobial and antifungal activities. This study was aimed at assessing the anti-fungal activity of essential oil from  Mentha suaveolens  (EOMS) in an experimental infection of vaginal candidiasis.    Methods  The  in vitro  and  in vivo  activity of EOMS was assessed. The  in vitro  activity was evaluated under standard CLSI methods, and the  in vivo  analysis was carried out by exploiting a novel, non-invasive model of vaginal candidiasis in mice based on an  in vivo  imaging technique.  Differences between essential oil treated and saline treated mice were evaluated by the non-parametric Mann-Whitney U-test. Viable count data from a time kill assay and yeast and hyphae survival test were compared using the Student's t-test (two-tailed).    Results  Our main findings were: i) EOMS shows potent candidastatic and candidacidal activity in an  in vitro  experimental system; ii) EOMS gives a degree of protection against vaginal candidiasis in an  in vivo  experimental system.    Conclusions  This study shows for the first time that the essential oil of a Moroccan plant  Mentha suaveolens  is candidastatic and candidacidal  in vitro , and has a degree of anticandidal activity in a model of vaginal infection, as demonstrated in an  in vivo  monitoring imaging system. We conclude that our findings lay the ground for further, more extensive investigations to identify the active EOMS component(s), promising in the therapeutically problematic setting of chronic vaginal candidiasis in humans.

Beneficial effect of Mentha suaveolens essential oil in the treatment of vaginal candidiasis assessed by real-time monitoring of infection