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Background  Saponins isolated from plant sources have a number of traditional and industrial applications. Saponins have pharmacological effects like anti-inflammatory, molluscicidal, antimicrobial, antispasmodic, antidiabetic, anticancer, anticonvulsant, anthelmintic, antitussive and cytotoxic activities. The current work describes the anthelmintic and cytotoxic activities of crude saponins of  Achillea Wilhelmsii  and  Teucrium Stocksianum  as these plants are rich with saponins.    Methods  Brine shrimp cytotoxic activity of crude saponins was determined by Meyer et al. (1982) at test concentrations of 1000 μg/ml, 100 μg/ml, 10 μg/ml, 7.5 μg/ml, 5.0 μg/ml, 2.5 μg/ml and 1.25 μg/ml. Percentage mortality of test concentrations was determined. Similarly, in  vitro  anthelmintic activity was determined against roundworms, tapeworms and earthworms. Albendazole and piperazine citrate at concentration 10 mg/ml were used as standard anthelmintic drugs.    Results  Crude saponins of  Achillea wilhelmsii  (CSA) and  Teucrium stocksianum  (CST) had, respectively, cytotoxic activity with LC 50  values 2.3 ± 0.16 and 5.23 ± 0. 34 μg/ml. For in  vitro  anthelmintic activity, time for paralysis and death of parasites (parasiticidal activity) was noted. At concentration 40 mg/ml, crude saponins of  Achillea wilhelmsii  are 1.96 and 2.12 times more potent than albendazole against  Pheretima posthuma  and  Raillietina spiralis , respectively. Similarly, at concentration 40 mg/ml, crude saponins of  Teucrium stocksianum  (CST) has 1.89, 1.96 and 1.37 times more parasiticidal activity than albendazole against  Pheretima posthuma, Raillietina spiralis  and  Ascardia galli , respectively.    Conclusion  Crude saponins of  Achillea wilhelmsii  and  Teucrium stocksianum  have cytotoxic and anthelmintic activity. The crude saponins may be excellent sources of cytotoxic and anthelmintic constituents that warrant its isolation and purification for new drug development.

Cytotoxic and anthelmintic potential of crude saponins isolated from Achillea Wilhelmsii C. Koch and Teucrium Stocksianum boiss