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Background   Aggregatibacter actinomycetemcomitans  ( A.actinomycetemcomitans ) is an important periodontal pathogen that can participate in periodontitis and other non-oral infections. The cytolethal distending toxin (Cdt) is among the virulence factors produced by this bacterium. This study was to elucidate the distribution of  A.actinomycetemcomitans  and the prevalence of its  cdtB  gene in Chinese subjects.    Methods  A total of 255 subgingival samples were obtained from 30 subjects. Samples were collected from periodontal healthy sites as well as shallow, moderate and deep pockets. The absolute quantity of  A.actinomycetemcomitans  and  cdtB  gene were determined by real-time polymerase chain reaction.    Results   A.actinomycetemcomitans  was detected in 92 of 105 (87.6%) samples of aggressive periodontitis (AgP) patients, in 73 of 79 (92.4%) samples of chronic periodontitis ( CP) patients and in 5 of 71 (7.0%) samples of periodontal healthy subjects. The  cdt B gene was detected in 72 sites (78.3%) with AgP infected with  A.actinomycetemcomitans , 54 sites (74.0%) with CP infected with  A.actinomycetemcomitans  and none in healthy sites infected with  A.actinomycetemcomitans . In addition, quantity of  A.actinomycetemcomitans  and  cdt  gene in samples from deep pockets were significant larger than moderate, shallow and healthy sites (P < 0.05). In comparison to CP, AgP patients were infected with increased numbers of  cdt  genotype in deep pockets (P < 0.05).    Conclusion  This study suggests that the  cdtB  gene are prevalent in  A.actinomycetemcomitans , and the distribution of  cdt  genotype strain may be correlated with AgP and serious periodontal inflammation.

Prevalence and distribution of Aggregatibacter actinomycetemcomitans and its cdtB gene in subgingival plaque of Chinese periodontitis patients