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Background   Candida albican s is a dimorphic fungus that is part of the commensal microbial flora of the oral cavity. When the host immune defenses are impaired or when the normal microbial flora is disturbed,  C. albicans  triggers recurrent infections of the oral mucosa and tongue. Recently, we produced NOD/SCID. e2f1  -/-  mice that show hyposalivation, decrease of salivary protein flow, lack IgA and IgG in saliva, and have decreased NK cells. Our objective was to characterize  C. albicans  infection and biofilm formation in mice .Methods  NOD/SCID. e2f1  -/-  mice were used as an animal model for  C. albicans  infection.  C. albicans  yeast and hyphal forms solutions were introduced in the oral cavity after disinfection by Chlorhexidine.    Results  The numbers of  C. albicans  colonized and decreased in a time-dependent manner in NOD/SCID .e2f1  +/+  after inoculation. However, the colonization levels were higher in NOD/SCID .e2f1  +/+  than NOD/SCID. e2f1  -/-  mice. In the mice fed 1% sucrose water before inoculation,  C. albicans  sample was highly contaminated by indigenous microorganisms in the oral cavity; and was not in the mice fed no sucrose water. The colonization of  C. albicans  was not influenced by the contamination of indigenous microorganisms. The hyphal form of  C. albicans  restricted the restoration of indigenous microorganisms. The decreased saliva in NOD/SCID. e2f1  -/-  did not increase the colonization of  C. albicans  in comparison to NOD/SCID .e2f1  +/+  mice .  We suggest that the receptor in saliva to  C. albicans  may not be sufficiently provided in the oral cavity of NOD/SCID. e2f1  -/-  mice.    Conclusion  The saliva protein flow may be very important for  C. albicans  initial colonization, where the indigenous microorganisms do not affect colonization in the oral cavity .

Effects of salivary protein flow and indigenous microorganisms on initial colonization of Candida albicans in an in vivo model