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Background  Sarcoidosis patients have accumulations of activated CD4 +  T cells in affected organs, such as the lungs. T cell receptor (TCR) Vβ-chain usage has been incompletely characterized in these patients .Methods  We surveyed the TCR Vβ usage in CD4 +  and CD8 +  T cells in bronchoalveolar lavage (BAL) cells and peripheral blood mononuclear cells (PBMC) from 15 HLA-typed Scandinavian sarcoidosis patients. In addition, PBMC from 9 healthy volunteers and BAL cells from three of them were examined. Using 21 Vβ family-specific antibodies, we covered approximately 70% of all Vβ chains.    Results  In BAL T cells from sarcoidosis patients, we identified 16 CD4 +  T cell expansions in 271 analyses (5.9%) and 21 CD8 +  expansions in 240 analyses (8.7%). In PBMC we found 9 CD4 +  expansions in 276 analyses (3.3%) and 12 CD8 +  expansions out of 263 analyses (4.6%). Consistent with previous studies we found Vβ8 and Vβ16 expansions in sarcoidosis patients’ lungs. In addition, we found lung restricted Vβ22 expansions in three HLA DRB1 03 +  patients. However, we found no statistically significant difference in frequency of expansions between patients and healthy controls.    Conclusions  The identified T cell expansions in present study indicate specific antigen recognition in the lungs of sarcoidosis patients.

T cell receptor-Vβ repertoires in lung and blood CD4+ and CD8+T cells of pulmonary sarcoidosis patients