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Background  In Sub Saharan Africa, the incidence of hypertension and other modifiable cardiovascular risk factors is growing rapidly. Poor adherence to prescribed prevention and treatment regimens by patients can compromise treatment outcomes. Patient-centered cardiovascular health education is likely to improve shortcomings in adherence. This paper describes a study that aims to develop a cardiovascular health education program for patients participating in a subsidized insurance plan in Nigeria and to evaluate the applicability and effectiveness in patients at increased risk for cardiovascular disease.    Methods/Design   Design:  The study has two parts. Part  1  will develop a cardiovascular health education program, using qualitative interviews with stakeholders. Part  2  will evaluate the effectiveness of the program in patients, using a prospective (pre-post) observational design.   Setting:  A rural primary health center in Kwara State, Nigeria.   Population:  For part 1: 40 patients, 10 healthcare professionals, and 5 insurance managers. For part 2: 150 patients with uncontrolled hypertension or other cardiovascular risk factors after one year of treatment.   Intervention:  Part  2 : patient-centered cardiovascular health education program.   Measurements:  Part 1: Semi-structured interviews to identify stakeholder perspectives. Part 2: Pre- and post-intervention assessments including patients' demographic and socioeconomic data, blood pressure, body mass index and self-reporting measures on medication adherence and perception of care. Feasibility of the intervention will be measured using process data.   Outcomes:  For program development (part 1): overview of healthcare professionals' perceptions on barriers and facilitators to care, protocol for patient education, and protocol implementation plan.  For program evaluation (part 2): changes in patients' scores on adherence to medication and life style changes, blood pressure, and other physiological and self-reporting measures at six months past baseline.   Analysis:  Part 1: content analytic technique utilizing MAXQDA software. Part 2: univariate and multilevel analysis to assess outcomes of intervention.    Discussion  Diligent implementation of patient-centered education should enhance adherence to cardiovascular disease prevention and management programs in low income countries.    Trial Registration   ISRCTN47894401

Development and evaluation of a patient centered cardiovascular health education program for insured patients in rural Nigeria (QUICK - II)