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Abstract Background Several studies have suggested an association between the functional <it>Val158Met </it>polymorphism in the <it>Catechol-O-Methyltransferase </it>(<it>COMT</it>) gene and neurocognitive performance. Two studies showed that subjects with the low activity <it>Met </it>allele performed better on the Wisconsin Card Sorting Test (WCST) and another study found an effect on processing speed and attention. Methods We set out to examine the association between the <it>Val158Met </it>polymorphism and performance on neurocognitive tasks including those tapping working memory, attention and speed, impulsiveness and response inhibition in a sample of 124 children with ADHD. Task performance for each genotypic group was compared using analysis of variance. Results There was no evidence of association with performance on any of the neurocognitive tasks. Conclusions We conclude <it>that Val158Met COMT </it>genotype is not associated with neurocognitive performance in our sample.</p

bmc psychiatry

No evidence of association between Catechol-O-Methyltransferase (COMT) Val 158 Met genotype and performance on neuropsychological tasks in children with ADHD: A case-control study