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Background  Prostate cancer is a frequent finding in man. In dogs, malignant disease of the prostate is also of clinical relevance, although it is a less common diagnosis. Even though there are numerous differences in origin and development of the disease, man and dog share many similarities in the pathological presentation. For this reason, the dog might be a useful animal model for prostate malignancies in man.  Although prostate cancer is of great importance in veterinary medicine as well as in comparative medicine, there are only few cell lines available. Thus, it was the aim of the present study to determine whether the formerly established prostate carcinoma cell line CT1258 is a suitable tool for  in vivo  testing, and to distinguish the growth pattern of the induced tumours.    Methods  For characterisation of the  in vivo  behaviour of the  in vitro  established canine prostate carcinoma cell line CT1258, cells were inoculated in 19 NOD.CB17- Prkdc   Scid  /J (in the following: NOD-Scid) mice, either subcutaneously or intraperitoneally. After sacrifice, the obtained specimens were examined histologically and compared to the pattern of the original tumour in the donor.  Cytogenetic investigation was performed.    Results  The cell line CT 1258 not only showed to be highly tumourigenic after subcutaneous as well as intraperitoneal inoculation, but also mimicked the behaviour of the original tumour.    Conclusion  Tumours induced by inoculation of the cell line CT1258 resemble the situation in naturally occurring prostate carcinoma in the dog, and thus could be used as  in vivo  model for future studies.

Establishing an in vivo model of canine prostate carcinoma using the new cell line CT1258