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Background The presence of sarcomatous components (SC) in gonadal or extragonadal germ cell tumors (GCT) is an infrequent phenomenon whose clinical outcome and biological significance remains unsettled. It may cause diagnostic pitfalls and treatment failure. In order to define the clinical and pathological characteristics, prognosis and biological behavior of these tumors, a clinicopathologic study of 48 cases of GCT/SC was undertaken, with immunohistochemical studies (IHCS) in 34 of them to define the phenotype of SC.

Germ-cell tumors with sarcomatous components. A clinicopathologic and immunohistochemical study of 48 cases