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Background Breast cancer is the most prevalent cancer in the world due to high incidence and favorable prognoses. Relapse is the major cause of mortality and will occur in up to 65% of patients with node-positive disease. Thus, effective longterm protection strategies are needed for preventing relapse. One approach that has generated interest in recent years is cancer vaccines. One of the problems with the translation of cancer vaccines is that multiple boosters are required in order to generate high-avidity memory immunity that is able to recognize naturally processed antigens. Our goal in this study was to determine if the need for boosters could be eliminated by preconditioning the immune system with anti-CD25 antibodies, which is known to deplete regulatory T cells, the latter of which are known to regulate the development of high-avidity memory T cells.

Breast cancer vaccines: maximizing peptide-based vaccines by regulatory T cell depletion and toll-like receptor 9 activation