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Background Chemoradiation based on weekly cisplatin is the standard treatment for locally advanced cervical cancer; however, the nephrotoxic potential and the requirement for hydration of cisplatin somewhat restrains its use. We previously reported that the recommended dose of carboplatin to be used weekly with radiation was 133 mg/m2 (IJROBP 2003). Hence, we wanted to analyze our results of treatment with carboplatin chemoradiation which was adopted as routine treatment in our Institution for patients having high risk conditions to develop renal dysfunction by cisplatin.

Concurrent chemoradiation with carboplatin for locally advanced cervical cancer at high-risk for developing cisplatin-induced renal dysfunction