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Background  Cytochrome  P 450 (CYP) enzymes have the potential to affect colorectal cancer (CRC) risk by determining the genotoxic impact of exogenous carcinogens and levels of sex hormones.    Methods  To investigate if common variants of  CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1  and  CYP19A1  influence CRC risk we genotyped 2,575 CRC cases and 2,707 controls for 20 single nucleotide polymorphisms (SNPs) that have not previously been shown to have functional consequence within these genes.    Results  There was a suggestion of increased risk, albeit insignificant after correction for multiple testing, of CRC for individuals homozygous for  CYP1B1  rs162558 and heterozygous for  CYP1A2  rs2069522 (odds ratio [OR] = 1.36, 95% confidence interval [CI]: 1.03–1.80 and OR = 1.34, 95% CI: 1.00–1.79 respectively).    Conclusion  This study provides some support for polymorphic variation in  CYP1A2  and  CYP1B1  playing a role in CRC susceptibility.

Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1and colorectal cancer risk