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Background  Long non-coding RNAs have been shown to have critical regulatory roles in cancer biology. However, the contributions of lncRNAs to gastric cancer remain largely unknown.    Methods  The differential expression of lncRNAs in gastric cancer and paired non-cancerous tissues were identified by microarray and validated using quantitative real-time PCR. Gastric samples from patients with gastric cancer were further analyzed for levels of a specifically downregulated lncRNA (termed as  LEIGC ).    Results  We found that there were significantly lower levels of  LEIGC  expression in cancer tissue than in adjacent non-cancerous tissues in human gastric cancers ( P  < 0.01). Overexpression of  LEIGC  suppressed tumor growth and cell proliferation, and enhanced the sensitivity of gastric cancer cells to 5-fluorouracil (5-FU), whereas knockdown of  LEIGC  showed the opposite effect. We further demonstrated  LEIGC  functions by inhibiting the epithelial-to-mesenchymal transition (EMT) in gastric cancer.    Conclusions  Our data suggested that  LEIGC  is a tumor-suppressing lncRNA in gastric cancer, and led us to propose that lncRNAs may play important regulatory roles in cancer development and progression.    Electronic supplementary material  The online version of this article (doi:10.1186/1471-2407-14-932) contains supplementary material, which is available to authorized users.

LEIGClong non-coding RNA acts as a tumor suppressor in gastric carcinoma by inhibiting the epithelial-to-mesenchymal transition