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Background  Genetic variants in inflammation-related genes have been associated with biliary stones and biliary tract cancers in previous studies.    Methods  To follow-up on these findings, we examined 35 single nucleotide polymorphism (SNPs) in 5 genes related to inflammation ( IL8 ,  NFKBIL ,  RNASEL ,  TNF ,  and VEGFA ) in 456 participants with incident biliary tract cancer cases (262 gallbladder, 141 extrahepatic bile duct, 53 ampulla of Vater), 982 participants with biliary stones, and 860 healthy controls in a population–based case–control study in Shanghai, China.    Results  Suggestive associations were observed for SNPs in  VEGFA  with biliary stones,  IL8  with gallbladder and ampulla of Vater cancers, and  RNASEL  with ampulla of Vater cancer (false discovery rate≤0.2).    Conclusion  These findings provide additional support for the role of inflammation in biliary stones and biliary tract cancer risk and need further validation.

Inflammatory gene variants and the risk of biliary tract cancers and stones: a population-based study in China