English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background  Promoter methylation of the tumor suppressor gene  Cyclin A1  could be associated with Human Papillomavirus 16 (HPV16) induced Head and Neck Squamous Cell Carcinoma (HNSCC) and Cervical Carcinoma. There is disagreement about the impact of this epigenetic event on protein expression of  Cyclin A1  in malignant and non-malignant tissue and there hardly exists any information about possible relationships between  Cyclin A1  expression and clinicopathological characteristics in HNSCC.    Methods  We analyzed protein expression of  Cyclin A1  in 81 HNSCC and 74 benign tonsils by immunohistochemistry and correlated it to  Cyclin A1  methylation status, presence of HPV16 infection and other clinicopathological characteristics.    Results  Overexpression of  Cyclin A1  was more present in HNSCC than in tonsils (p < 0.001). In both entities, HNSCC and benign tonsils, expression of  Cyclin A1  significantly correlated with the expression of Cyclin-dependent kinase-inhibitor  p16  (p = 0.000672 and 0.00495). In tonsils, expression of  Cyclin A1  was inversely proportional to age (p = 0.396), and further correlated with expression of tumor suppressor gene  p53  (p = 0.000228). In HNSCC  Cyclin A1  expression was associated with the presence of HPV16 DNA (p = 0.0014) and a lower recurrence rate in univariate and multivariate analysis (p = 0.002 and 0.013). Neither in HNSCC nor in tonsils  Cyclin A1  expression correlated with promoter methylation.    Conclusions   Cyclin A1  is an important cell cycle regulator with age-related increased expression in tonsils of children. HPV16 induces overexpression of  Cyclin A1  in HNSCC despite promoter methylation. Overexpression of  Cyclin A1  predicts a lower recurrence rate in HNSCC independently of HPV16.

bmc cancer

Cyclin A1 shows age-related expression in benign tonsils, HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate in HNSCC independently of HPV16