English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  A rural region in south-west Spain has one of the highest lung cancer incidence rates of the country, as revealed by a previous epidemiological 10-year follow-up study. The present work was undertaken to ascertain the role of  CYP1A1  gene polymorphisms and their interaction with tobacco smoking in the development of the disease in this location.    Methods  One-hundred-and-three cases of lung cancer and 265 controls participated in the study. The participants were screened for the presence of four  CYP1A1  polymorphisms, namely  MspI , Ile462Val, T3205C, and Thr461Asn. Lung cancer risk was estimated as odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression models adjusting for age, sex, and smoking.    Results  The distribution of the variant  CYP1A1  alleles was different from that described for other Caucasian populations, with  CYP1A1*2A  showing an uncommonly high frequency (p < 0.01). The  CYP1A1*2B  allele (carrying  MspI  and Ile462Val mutations) was strongly associated with high lung cancer risk (OR = 4.59, CI:1.4-12.6,  p  <0.01). The Ile462Val polymorphism was also shown to increase the risk for the disease (OR = 4.51, CI:1.8-11.9;  p  <0.01) and particularly for squamous-cell (OR = 5.01; CI: 1.6-14.3, p < 0.01) and small-cell lung carcinoma (SCLC) (OR = 6.97, CI: 1.2-81.3;  p  = 0.04). Moreover, the Thr461Asn polymorphism was found to be associated with SCLC in a Caucasian population for the first time to our knowledge (OR = 8.33, CI: 1.3-15.2,  p  = 0.04).    Conclusion  The results suggest that  CYP1A1  polymorphisms contribute to increase lung cancer susceptibility in an area with an uncommon high incidence rate.

CYP1A1gene polymorphisms increase lung cancer risk in a high-incidence region of Spain: a case control study