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Background  The endothelial nitric oxide synthase gene ( NOS3 ) has been proposed as a candidate gene for preeclampsia. However, studies so far have produced conflicting results. This study examines the specific role of variants and haplotypes of the  NOS3  gene in a population of Caucasian origin.    Methods  We examined the association of three common variants of the  NOS3  gene (4b/a, T-786C and G894T) and their haplotypes in a case-control sample of 102 patients with preeclampsia and 176 women with a history of uncomplicated pregnancies. Genotyping for the  NOS3  variants was performed and odds ratios and 95% confidence intervals were obtained to evaluate the association between  NOS3  polymorphisms and preeclampsia.    Results  The single locus analysis for the three variants using various genetic models and a model-free approach revealed no significant association in relation to clinical status. The analysis of haplotypes also showed lack of significant association.    Conclusions  Given the limitations of the candidate-gene approach in investigating complex traits, the evidence of our study does not support the major contributory role of these common  NOS3  variants in preeclampsia. Future larger studies may help in elucidating the genetics of preeclampsia further.

Polymorphisms of the endothelial nitric oxide synthase (NOS3) gene in preeclampsia: a candidate-gene association study