English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Yearly

Global: Zendy Monthly

Background  Pathological brain iron deposition has been implicated as a source of neurotoxic reactive oxygen species in Alzheimer (AD) and Parkinson diseases (PD). Iron metabolism is associated with the gene hemochromatosis ( HFE  Human genome nomenclature committee ID:4886), and mutations in  HFE  are a cause of the iron mismetabolism disease, hemochromatosis. Several reports have tested the association of  HFE  variants with neurodegenerative diseases, such as AD and PD with conflicting results.    Methods  Genotypes were analysed for the two most common variants of  HFE  in a series of 130 AD, 55 Mild Cognitive Impairment (MCI) and 132 PD patients. Additionally, a series of 115 healthy age-matched controls was also screened.    Results  A statistically significant association was found in the PD group when compared to controls, showing that the presence of the C282Y variant allele may confer higher risk for developing the disease.    Conclusion  Taken together these results suggest that the common variants in  HFE  may be a risk factor for PD, but not for AD in the Portuguese population.

Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort