English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background  The Chronic Kidney Disease Epidemiology Collaboration equation for estimation of glomerular filtration rate (eGFR CKD-EPI ) improves GFR estimation compared with the Modification of Diet in Renal Disease Study equation (eGFR MDRD ) but its association with mortality in a nationally representative population sample in the US has not been studied.    Methods  We examined the association between eGFR and mortality among 16,010 participants of the Third National Health and Nutrition Examination Survey (NHANES III). Primary predictors were eGFR CKD-EPI  and eGFR MDRD . Outcomes of interest were all-cause and cardiovascular disease (CVD) mortality. Improvement in risk categorization with eGFR CKD-EPI  was evaluated using adjusted relative hazard (HR) and Net Reclassification Improvement (NRI).    Results  Overall, 26.9% of the population was reclassified to higher eGFR categories and 2.2% to lower eGFR categories by eGFR CKD-EPI,  reducing the proportion of prevalent CKD classified as stage 3–5 from 45.6% to 28.8% .  There were 3,620 deaths (1,540 from CVD) during 215,082 person-years of follow-up (median, 14.3 years). Among those with eGFR MDRD  30–59 ml/min/1.73 m 2 , 19.4% were reclassified to eGFR CKD-EPI  60–89 ml/min/1.73 m 2  and these individuals had a lower risk of all-cause mortality (adjusted HR, 0.53; 95% CI, 0.34-0.84) and CVD mortality (adjusted HR, 0.51; 95% CI, 0.27-0.96) compared with those not reclassified. Among those with eGFR MDRD  >60 ml/min/1.73 m 2 , 0.5% were reclassified to lower eGFR CKD-EPI  and these individuals had a higher risk of all-cause (adjusted HR, 1.31; 95% CI, 1.01-1.69) and CVD (adjusted HR, 1.42; 95% CI, 1.01-1.99) mortality compared with those not reclassified. Risk prediction improved with eGFR CKD-EPI ; NRI was 0.21 for all-cause mortality (p < 0.001) and 0.22 for CVD mortality (p < 0.001).    Conclusions  eGFR CKD-EPI  categories improve mortality risk stratification of individuals in the US population. If eGFR CKD-EPI  replaces eGFR MDRD  in the US, it will likely improve risk stratification.

bmc nephrology

Comparing the association of GFR estimated by the CKD-EPI and MDRD study equations and mortality: the third national health and nutrition examination survey (NHANES III)