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Background  Several lines of evidence suggest that chemokines and cytokines play an important role in the inflammatory development and progression of systemic lupus erythematosus. The aim of this study was to evaluate the relevance of functional genetic variations of  RANTES, IL-8 ,  IL-1α , and  MCP-1  for systemic lupus erythematosus.    Methods  The study was conducted on 500 SLE patients and 481 ethnically matched healthy controls. Genotyping of polymorphisms in the  RANTES, IL-8 ,  IL-1α , and  MCP-1  genes were performed using a real-time polymerase chain reaction (PCR) system with pre-developed TaqMan allelic discrimination assay.    Results  No significant differences between SLE patients and healthy controls were observed when comparing genotype, allele or haplotype frequencies of the  RANTES ,  IL-8 ,  IL-1α , and  MCP-1  polymorphisms. In addition, no evidence for association with clinical sub-features of SLE was found.    Conclusion  These results suggest that the tested functional variation of  RANTES ,  IL-8, IL-1α , and  MCP-1  genes do not confer a relevant role in the susceptibility or severity of SLE in the Spanish population.

Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus