English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Genome-wide association studies found common variants in the fat mass and obesity-associated ( FTO ) gene associated with adiposity in Caucasians and Asians but the association was not confirmed in African populations. Association of  FTO  variants with insulin resistance and energy intake showed inconsistent results in previous studies. This study aimed to assess the influence of  FTO  variant rs9939609 on adiposity, insulin resistance, energy intake and physical activity in European - (EA) and African-American (AA) youth.    Methods  We conducted a cross-sectional study in EA and AA youths. One thousand, nine hundred and seventy-eight youths (48.2% EAs, 47.1% male, mean age 16.5 years) had measures of anthropometry. Percent body fat (%BF) was measured by dual-energy X-ray absorptiometry, visceral adipose tissue (VAT) and subcutaneous abdominal adipose tissue (SAAT) by magnetic resonance imaging. Energy intake and physical activity were based on self report from up to 7 24-hour recalls. Physical activity was also measured by accelerometry.    Results   FTO  rs9939609 was significantly associated with body mass index (BMI) ( P  = 0.01), weight ( P  = 0.03) and waist circumference ( P  = 0.04), with per-allele effects of 0.4 kg/m 2 , 1.3 kg and 0.8 cm, respectively. No significant association was found between rs9939609 and %BF, VAT, SAAT or insulin resistance ( P  > 0.05), or between rs9939609 and energy intake or vigorous physical activity ( P  > 0.05). No significant interactions of rs9939609 with ethnicity, gender, energy intake or physical activity were observed ( P  > 0.05).    Conclusions  The  FTO  variant rs9939609 is modestly associated with BMI and waist circumference, but not with energy intake or physical activity. Moreover, these effects were similar for EAs and AAs. Improved understanding of the effect of the  FTO  variant will offer new insights into the etiology of excess adiposity.

bmc medical genetics

FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth