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Background  Late onset Alzheimer's disease (LOAD) is a neurodegenerative disorder characterised by the deposition of amyloid plaques and neurofibrillary tangles in the brain and is the major cause of dementia. Multiple genetic loci, including 10q, have been implicated in LOAD but to date, with the exception of  APOE , the underlying genes have not been identified.  HECTD2  maps to 10q and has been implicated in susceptibility to human prion diseases which are also neurodegenerative conditions associated with accumulation of misfolded host proteins. In this study we test whether the  HECTD2  susceptibility allele seen in prion disease is also implicated in LOAD.    Methods  DNA from 320 individuals with Alzheimer's disease and 601 controls were genotyped for a  HECTD2  intronic tagging SNP,  rs12249854  (A/T). Groups were further analysed following stratification by  APOE  genotype.    Results  The  rs12249854  minor allele (A) frequency was higher (5.8%) in the Alzheimer's disease group as compared to the controls (3.9%), however, this was not statistically significant (P = 0.0668). No significant difference was seen in minor allele frequency in the presence or absence of the  APOE  ε4 allele.    Conclusion  The common haplotypes of  HECTD2 , tagged by  rs12249854 , are not associated with susceptibility to LOAD.

HECTD2, a candidate susceptibility gene for Alzheimer's disease on 10q