English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Association of the interleukin-23 receptor ( IL23R ) with inflammatory bowel disease (IBD) has been confirmed in several populations.  IL23R  also associates with psoriasis, suggesting that the gene may be an important candidate for many chronic inflammatory diseases.    Methods  We studied association of single-nucleotide variants in  IL23R  with IBD in Swedish patients, in both Crohn's disease (CD) and ulcerative colitis (UC) subsets. The same genetic variants were also studied in Finnish patients with psoriasis or celiac disease, and in Hungarian and Italian patients with celiac disease.    Results  Association of  IL23R  with IBD was replicated in our Swedish patients, and linkage and association of the  IL23R  region with psoriasis was found in the Finnish population. The  IL23R  region was also linked to celiac disease in Finnish families, but no association of  IL23R  variants with celiac disease was found in the Finnish, Hungarian or Italian samples.    Conclusion  Our study is the first to demonstrate association of  IL23R  with CD and UC in Swedish patients with IBD. It is also the first study to report linkage and association of the  IL23R  region with psoriasis in the Finnish population. Importantly, this is the first report of linkage of the  IL23R  region to celiac disease, a chronic inflammatory condition in which  IL23R  has not been previously implicated.

IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease