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Background  The pathogenesis of severe acute respiratory disease syndrome (SARS) is not fully understood. One case-control study has reported an association between susceptibility to SARS and  mannan-binding lectin  ( MBL ) in China. As the downstream protein of  MBL , variants of the  MBL -associated serine protease-2 ( MASP2 ) gene may be associated with SARS coronavirus (SARS-CoV) infection in the same population.    Methods  Thirty individuals with SARS were chosen for analysis of  MASP2  polymorphisms by means of PCR direct sequencing. Tag single nucleotide polymorphisms (tagSNPs) were chosen using pairwise tagging algorithms. The frequencies of four tag SNPs (rs12711521, rs2261695, rs2273346 and rs7548659) were ascertained in 376 SARS patients and 523 control subjects, using the Beckman SNPstream Ultra High Throughput genotyping platform.    Results  There is no significant association between alleles or genotypes of the  MASP2  tagSNP and susceptibility to SARS-CoV in both Beijing and Guangzhou populations. Diplotype (rs2273346 and rs12711521)were analyzed for association with susceptibility to SARS, no statistically significant evidence of association was observed. The Beijing and Guangzhou sample groups were homogeneous regarding demographic and genetic parameters, a joined analysis also showed no statistically significant evidence of association.    Conclusion  Our data do not suggest a role for  MASP2  polymorphisms in SARS susceptibility in northern and southern China.

Lack of association between polymorphisms of MASP2and susceptibility to SARS coronavirus infection