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Background  The functional polymorphism -260 C>T in the LPS sensing TLR4 co-receptor  CD14  gene enhances the transcriptional activity and results in a higher CD14 receptor density. Individuals carrying the T/T genotype also have significantly higher serum levels of soluble CD14. The T allele of this polymorphism has recently been linked to  Chlamydia pneumoniae  infection. We investigated the role of the  CD14  -260 C>T polymorphism in the susceptibility to and severity (defined as subfertility and/or tubal pathology) of  C. trachomatis  infection in Dutch Caucasian women.    Methods  The different  CD14  -260 C>T genotypes were assessed by PCR-based RFLP analysis in three cohorts: 1) A cohort (n = 576) of women attending a STD clinic, 2) a cohort (n = 253) of women with subfertility, and 3) an ethnically matched control cohort (n = 170). The following variables were used in the analysis: In cohort 1 the CT-DNA status, CT IgG serology status, self-reported symptoms and in cohort 2, the CT IgG serology status and the tubal status at laparoscopy.    Results  In the control cohort the CC, CT and TT genotype distribution was: 28.2%, 48.2%, and 23.5% respectively. No differences were found in the overall prevalence of  CD14  -260 genotypes (28.1%, 50.7%, and 21.2%) in cohort 1 when compared to the control cohort. Also no differences were observed in women with or without CT-DNA, with or without serological CT responses, with or without symptoms, or in combinations of these three variables. In subfertile women with tubal pathology (cohort 2, n = 50) the genotype distribution was 28.0%, 48.0%, and 24.0% and in subfertile women without tubal pathology (n = 203), 27.6%, 49.3% and 23.2%. The genotype distribution was unchanged when CT IgG status was introduced in the analyses.    Conclusion  The  CD14  -260 C>T genotype distributions were identical in all three cohorts, showing that this polymorphism is not involved in the susceptibility to or severity of sequelae of  C. trachomatis  infection.

bmc infectious diseases

The CD14 functional gene polymorphism -260 C&gt;T is not involved in either the susceptibility to Chlamydia trachomatis infection or the development of tubal pathology