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Results We examined 149 strains of S. aureus, 44.9% from cutaneous wound infections, 31.2% from blood cultures, 8.4% from sputum samples and 15.3% from other infection sites. Of the total number of strains identified, 55.7% were resistant to methicillin, 35.1% were resistant to clindamycin (D-test results are presented separately), 30.9% were resistant to levofloxacin, 18.7% were resistant to rifampin and smaller percentages were identified for resistance to other drugs. Surprisingly, resistance was also identified to drugs that are not used in clinical practice in Romania, such as daptomycin (6.8%) or fusidic acid (4.8%), suggesting a possible international circulation of S. aureus strains, probably through means of nasal or axillary carriage. We excluded a mechanism of daptomycin non-susceptibility through thickened bacterial cell walls in strains of vancomycin-intermediate S. aureus, as all strains were susceptible to vancomycin.

Resistance profile of Staphylococcus aureusstrains isolated from patients treated in a tertiary care hospital in Romania