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Background Trimethoprim-sulfamethoxazole (TMP-SMX) is a broad spectrum antimicrobial agent and also reduces the mortality among adults and children when used as prophylaxis against opportunistic infections in HIV infected patients. Drug resistant to TMP-SMX along with Extended spectrum b-lactamase (ESBL) production among Enterobacteriaceae is creating major therapeutic problem in clinical settings for treating the bacterial infections among HIV individuals.

Trimethoprim sulfamethoxazole drug resistance with co resistance to extended spectrum β-lactam antibiotics among bacterial isolates from HIV patients