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In HIV-1 infection, some rare patients called HIV controllers (HICs) are capable to spontaneously control viral replication in vivo. Interestingly, HICs exhibit higher frequency of a particular activated phenotype CD38-HLA-DR+ HIV-specific CD8+ T cells. The aim of this study was to characterize this profile and evaluate its role in HICs.

The potential role of HIV-specific CD38-/HLA-DR+ CD8+ T cells in viral suppressive activity and cytotoxicity in HIV controllers