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Results In this study, 12.26% (394/3215) of the pregnant women were diagnosed HIV-positive, 0.52% (2/388) overall residual rate of transmission was identified with rates of 1.75% (2/114) among mothers under prophylaxis and 0.00% (0/274) for those under HAART. Genetic mutations have also been isolated that induce resistance to ARVs like M184V, Y115F, K103N, Y181C, v179E, G190A, etc. And there were subtypes and circulating recombinant forms (CRF) of HIV-1 such as: CRF06_CPX (58.8%), CRF02_AG (35.3%) and subtype G (5.9%). Conclusion Antiretroviral drugs reduce the residual rate of HIV vertical transmission. However, they cause mutations that induce resistance of HIV to antiretroviral therapy. Resistance to ARV therefore requires a permanent dialogue between clinicians, prescribers, pharmacists, and the creation of a network of monitoring and surveillance of drug resistance in Burkina Faso.

bmc infectious diseases

PMTCT of HIV-1 in Burkina Faso: evaluation of residual vertical transmission by PCR, molecular characterization of subtypes and determination of antiretroviral drugs resistance