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Background  Infections by  Staphylococcus spp.  are often associated with wounds, especially in hospitalized patients. Wounds may be the source of bacteria causing cross-contamination, and are a risk factor for methicillin-resistant  Staphylococcus aureus  (MRSA) infection. The aim of this study was to investigate the prevalence of wound colonization by  Staphylococcus spp. , especially  S. aureus  and MRSA, in hospitalized patients, and to identify the factors associated with such colonization.    Methods  This cross-sectional study enrolled patients with wounds who were hospitalized in a remote and underdeveloped inland region of northeastern Brazil with extreme poverty. Samples were collected using sterile swabs with 0.85% saline solution, and coagulase-negative  Staphylococcus spp. ,  S. aureus,  and MRSA were identified using standard laboratory procedures. Data regarding the sociodemographic characteristics, antibiotic use, and comorbidities of the patients were collected using the medical records and a questionnaire.    Results  A total of 125 wounds were analyzed. The patients had a mean age of 63.88 years and a mean 3.84 years of school education. Eighty-one wounds (64.80%) were colonized by  Staphylococcus spp.  Twenty-five wounds (20%) were colonized by  S. aureus , 32% of which were colonized by MRSA. Wound colonization by  Staphylococcus spp.  was associated with pneumonia or other respiratory disease (p = 0.03). Wound colonization by  S. aureus  was associated with nasal colonization by  S. aureus  (p < 0.001), fewer days of prior antibiotic use (p = 0.04), admission to a medical ward (p = 0.02), and age >65 years (p = 0.05). Among patients with wound colonization by MRSA, 37.50% had a history of prior antibiotic use, 75% had two or more comorbidities, 25% had cancer or diabetes, 50% had cardiovascular disease, and 50% died.    Conclusions  Wounds can be the source of  Staphylococcus spp.  infection, and high proportions of wounds are colonized by  S. aureus  and MRSA. Nasal colonization by  S. aureus  may be a source for wound colonization by  S. aureus , illustrating the importance of preventing cross-contamination in hospital environments, especially among elderly patients. Wounds should be carefully managed to prevent microbial spread, thereby assisting patient recovery and reducing healthcare costs.

bmc infectious diseases

Prevalence and factors associated with wound colonization by Staphylococcus spp. and Staphylococcus aureusin hospitalized patients in inland northeastern Brazil: a cross-sectional study