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Case report We describe the case of a young adult known with hereditary microspherocytosis who presented with fever, marked agitation and confusion and a slight left hemiparesis. The cerebral imaging revealed multiple giant cystic VirchowRobin spaces, but no other abnormalities. The complete blood counts showed pancytopenia and the peripheral blood smear revealed reticulocytopenia, confirming the diagnosis of aplastic crisis. Human parvovirus B19 infection was proven by the detection of serum DNA using PCR technique. After the initiation of packed red cells transfusion a favorable outcome was seen and his neurologic symptoms fully remitted.

Aplastic crisis and transient neurological symptoms due to parvovirus B19 infection in a patient with chronic hemolytic disorder